The Mechanisms Underlying Chronic Inflammation in Rheumatoid Arthritis from the Perspective of the Epigenetic Landscape

Figure 1

Epigenetic disorders induce the activation of rheumatoid arthritis synovial fibroblasts (RASFs). Normal SFs are differentiated from mesenchymal stromal or stem cells (MSCs) under normal epigenetic regulation in noninflammatory joints of healthy individuals. The activation of SFs is caused by aberrant epigenetic changes in inflammatory joints of RA.