The Mechanisms Underlying Chronic Inflammation in Rheumatoid Arthritis from the Perspective of the Epigenetic Landscape

Table 3

Abnormality of miRNAs in RASFs.

miRNA	Expression change	Function	References
miR-34	Downregulation	Increase of XIAP involved in resistance to apoptosis	[99]
miR-203	Upregulation	Increase of MMP-1 involved in extracellular matrix degradation; Increase of IL-6 involved in inflammation	[100]
miR-155	Upregulation	Decrease of MMP-3 involved in extracellular matrix degradation	[101]
miR-155	Upregulation	Decrease of IKBKE involved in inflammation	[102]
miR-22	Downregulation	Increase of CYR61 involved in cell proliferation and Th17 cell differentiation	[103]
miR-20a	Downregulation	Increase of ASK1 involved in TLR4 pathway	[104]
miR-19b	Downregulation	Increase of TLR2 involved in innate immunity	[105]