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Journal of Immunology Research
Volume 2016, Article ID 6374379, 7 pages
Review Article

NK-DC Crosstalk in Immunity to Microbial Infection

Department of Immunology, Faculty of Medicine, University of Manitoba, 471 Apotex Centre, 750 McDermot Avenue, Winnipeg, MB, Canada R3E 0T5

Received 30 August 2016; Accepted 13 November 2016

Academic Editor: Anil Shanker

Copyright © 2016 Rony Thomas and Xi Yang. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The interaction between natural killer (NK) cell and dendritic cell (DC), two important cellular components of innate immunity, started to be elucidated in the last years. The crosstalk between NK cells and DC, which leads to NK cell activation, DC maturation, or apoptosis, involves cell-cell contacts and soluble factors. This interaction either in the periphery or in the secondary lymphoid organs acts as a key player linking innate and adaptive immune responses to microbial stimuli. This review focuses on the mechanisms of NK-DC interaction and their relevance in antimicrobial responses. We specifically aim to emphasize the ability of various microbial infections to differently influence NK-DC crosstalk thereby contributing to distinct adaptive immune response.