The Emerging Role of HMGB1 in Neuropathic Pain: A Potential Therapeutic Target for Neuroinflammation

Table 1

The cardinal etiologies of neuropathic pain.

Classification	Frequent etiology	Reference
Disease process	Infection/inflammation, immunity, tumor infiltration, metabolic abnormalities, neurotoxicity	[2, 11, 14–16]
Therapeutic intervention	Surgery, chemotherapy, irradiation	[17, 18]
Trauma	External injury, nerve compression	[19–21]
Genetic predisposition	Inherited neurodegeneration, metabolic abnormalities, endocrine abnormalities	[22, 23]