Impaired Cytokine Responses to Epstein-Barr Virus Antigens in Systemic Lupus Erythematosus Patients

Table 4

Correlation between induced cytokines and disease activity of SLE patients ().

Cytokine	SLEDAI	cSLEDAI	sSLEDAI
(A) EBNA1 stimulation
IL12	NS	NS	NS
IFNγ	NS	NS	−0.757 (0.001)
IL18	NS	NS	NS
IL4	NS	NS	−0.747 (0.001)
TNFα	NS	NS	−0.619 (0.014)
TNFβ	NS	NS	−0.548 (0.034)
IL6	NS	NS	NS
IL17	NS	NS	NS
IL10	NS	NS	NS
GM-CSF	NS	NS	NS
(B) EBV-EA/D stimulation
IL12	NS	NS	NS
IFNγ	NS	NS	NS
IL18	NS	NS	−0.610 (0.016)
IL4	NS	NS	−0.595 (0.019)
TNFα	NS	NS	NS
TNFβ	NS	NS	NS
IL6	NS	NS	−0.625 (0.013)
IL17	NS	NS	NS
IL10	NS	NS	−0.633 (0.011)
GM-CSF	NS	NS	NS

SLE: systemic lupus erythematosus; SLEDAI: SLE disease activity index; cSLEDAI: clinical SLEDAI; sSLEDAI: serologic SLEDAI; EBNA: Epstein-Barr virus (EBV) nuclear antigen; EBV-EA/D: Epstein-Barr virus early antigen diffuse; IL: interleukin; IFN: interferon; TNF: tumor necrosis factor; GM-CSF: granulocyte macrophage colony-stimulating factor; NS: not significant.
All values are spearman ( values).
SLEDAI: Systemic Lupus Erythematosus Disease Activity Index score.
cSLEDAI: SLEDAI score excluding anti-dsDNA, complement, thrombocyte, and leukocyte levels.
sSLEDAI: SLEDAI scores based on anti-dsDNA, complement, thrombocyte, and leukocyte levels.
NS: not significant.