Genetic Variation in the IL-6 and HLA-DQB1 Genes Is Associated with Spontaneous Clearance of Hepatitis C Virus Infection

Table 1

Candidate genes selection.

⁢Candidate genes associated with HCV spontaneous clearance or response to therapy
Gene symbol	Chromosome location	Gene name	Number of SNPs in analysis
IL28B	19q13.13	Interleukin 28B (encoding IFN-gamma-3)	4
SOCS3	17q25.3	Suppressor of cytokine signaling 3	16
SOCS1	16p13.13	Suppressor of cytokine signaling 1	2
IL-10	1q31-q32	Interleukin 10	15
IL-18	11q22.2-q22.3	Interleukin 18	6
TNF-alpha	6p21.3	Tumor necrosis factor alpha	1
TGF-beta-1	19q13.1	Transforming growth factor, beta 1	4
IL-6	7p21	Interleukin 6	42
CTLA-4	2q33	Cytotoxic T-lymphocyte-associated protein 4	7
IFNG	12q14	Interferon, gamma	8
HLA genes:
HLA-DRB1	6p21.3	Major histocompatibility complex, class II, DR beta 1	5
HLA-DQB1	6p21.3	Major histocompatibility complex, class II, DQ beta 1	40