Genetic Variation in the IL-6 and HLA-DQB1 Genes Is Associated with Spontaneous Clearance of Hepatitis C Virus Infection
Table 3
Likelihood ratio test (LRT) results comparing full models (consisting of all SNPs for the gene) and null models after controlling for HIV infection.
Not controlling for HIV
Controlling for HIV
Gene name
LRT p value
5% significance threshold
Gene name
LRT p value
5% significance threshold
HLA-DQB1
0.0006
HLA-DQB1
0.0005
IL-6
0.0007
0.0117
IL-6
0.0008
0.0110
IL-28B
0.1700
0.0347
IL28B
0.1600
0.0324
IL-10
0.1987
0.0697
IL-10
0.2603
0.0645
CTLA-4
0.4514
0.1124
CTLA4
0.4305
0.1059
HLA-DRB1
0.4981
0.1661
HLA-DRB1
0.4759
0.1602
SOCS1
0.5313
0.2264
SOCS1
0.5071
0.2195
TNF
0.6957
0.2952
TNF
0.6508
0.2888
IFNG
0.7391
0.3755
SOCS3
0.7475
0.3675
TGF-beta-1
0.7590
0.4677
TGF-beta-1
0.8025
0.4548
SOCS3
0.7742
0.5738
IFNG
0.8027
0.5630
IL-18
0.9567
0.7027
IL-18
0.9649
0.7037
5% significance thresholds derived from permutation distributions (unstratified). A gene reaches statistical significance under the step-down procedure when the observed LRT values for it and all more significant genes are less than their corresponding 5% thresholds.
