Association of Immunosuppression with DR6 Expression during the Development and Progression of Spontaneous Ovarian Cancer in Laying Hen Model

Figure 1

Gross presentation of spontaneous ovarian cancer (OVCA) in hens. (a) Ovary (OV) of a normal old laying hen showing few large preovulatory follicles (F1 and F2) and small developing follicles. The oviduct (OD) appears to be functional and no abnormalities are detected. (b) Ovary of a hen out of lay without large follicles. Both the ovary and the oviduct regressed remarkably. (c) Early stage OVCA in a hen. Tumor limited to the ovary with little ascites (). (d) Late stage OVCA in a hen accompanied with profuse ascites (). Tumor metastasized to other organs (arrows indicate examples of tumor metastasis).

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