Association of Immunosuppression with DR6 Expression during the Development and Progression of Spontaneous Ovarian Cancer in Laying Hen Model

Figure 9

DR6 expression in normal or tumor ovaries. (a) Normal ovary. Few stromal and granulosa cells of the follicle expressed DR6. (b-c) Ovarian tumors at early and late stages showing strong expression of DR6. (d) Western blotting detected the DR6 protein of 50–60 kDa in normal or malignant ovaries. Compared with the normal, stronger bands for DR6 proteins were observed in early and late stages of OVCA. (e) Semiquantitative mRNA expression assays showed strong amplification for DR6 in tumor compared with normal ovaries. F: follicle; G and T: granulosa and theca layers of the follicle, respectively; S: stroma; Tu: tumor. Magnification: 40x.

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