Systemic Administration of Proteoglycan Protects BALB/c Retired Breeder Mice from Experimental Arthritis

Figure 4

Effect of previous PG inoculation on local T cell transcription factors and cytokine levels. (a) T-bet, (b) ROR-γ, (c) GATA-3, and (d) Foxp3 mRNA expression in paw homogenates. Quantification was based on fold difference () between groups, using control (−) group as calibrator. (e) TNF-α and (f) IL-6 levels in paw homogenates assessed by Cytometric Bead Array. Control (+): arthritic group not previously injected with PG; 3xPG50: arthritic group previously injected with three doses of PG (50 μg). Hind and forepaws from six to ten animals per group from one representative experiment of two performed. .

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