Systemic Administration of Proteoglycan Protects BALB/c Retired Breeder Mice from Experimental Arthritis

Figure 5

Delayed-type hypersensitivity reaction elicited by PG in mice previously inoculated with PG or OVA. Paw thickness was measured before and 24 hours after PG challenge using a caliper. Control (−): healthy group not previously injected with PG; control (+): arthritic group not previously injected with PG; 3xPG50: arthritic group previously injected with three doses of PG (50 μg). Four to six animals per group from one representative experiment of two performed. .