Research Article

Systemic Administration of Proteoglycan Protects BALB/c Retired Breeder Mice from Experimental Arthritis

Table 1

Arthritis prevalence and severity in mice previously inoculated with proteoglycan. Arthritis score was daily evaluated and disease severity was assessed by a visual scoring system with total score ranging from 0 to 16 for each animal. Score above eight indicates severe arthritis. These parameters were compiled 70 days after arthritis induction. Control (+): arthritic group not previously injected with PG; 2xPG50, 2xPG100, and 3xPG50: arthritic groups previously injected with two (50 μg), two (100 μg), or three (50 μg) PG doses, respectively. Data from two independent experiments were combined.

Arthritis prevalence valueDisease onset (days)Animals with score > 8 value

Control (+)22/22 (100%)0.042439/22 (41%)<0.001
2xPG5012/13 (92%)440/13 (0%)
2xPG1007/7 (100%)440/7 (0%)
3xPG5012/16 (75%)430/16 (0%)