Dengue Fever: Causes, Complications, and Vaccine Strategies

Figure 3

DENV-1, DENV-2, DENV-3, and DENV-4 with EDIII (circled) in red, green, blue, and black, respectively. EDIIIs elicit strongly neutralizing serotype-specific antibodies (antibodies in bold). Owing to homology especially in domains (EDI/II and prM) in yellow, cross-reactive weakly neutralizing antibodies (unbold antibodies) and nonneutralizing enhancing antibodies (dashed antibodies) are elicited in bulk.