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Journal of Immunology Research
Volume 2016, Article ID 7121580, 17 pages
Review Article

Mesenchymal Stem Cells and Myeloid Derived Suppressor Cells: Common Traits in Immune Regulation

Central Tuberculosis Research Institute, Yauza Alley 2, Moscow 107564, Russia

Received 25 February 2016; Accepted 8 May 2016

Academic Editor: Moisés E. Bauer

Copyright © 2016 Irina Lyadova Vladimirovna et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


To protect host against immune-mediated damage, immune responses are tightly regulated. The regulation of immune responses is mediated by various populations of mature immune cells, such as T regulatory cells and B regulatory cells, but also by immature cells of different origins. In this review, we discuss regulatory properties and mechanisms whereby two distinct populations of immature cells, mesenchymal stem cells, and myeloid derived suppressor cells mediate immune regulation, focusing on their similarities, discrepancies, and potential clinical applications.