Characterization of Natural Killer Cells and Cytokines in Maternal Placenta and Fetus of Diabetic Mothers
Table 2
Percentage of cell phenotypes CD16+ and/or CD56+ in the placenta, maternal blood, and cord blood of groups without diabetes (ND) or with mild hyperglycemia (MGH), gestational diabetes mellitus (GDM), and diabetes mellitus (DM-2).
Cells (%)
Sample
ND ()
MGH ()
DGM ()
DM-2 ()
CD16+ CD56−
Maternal blood
12.85 ± 6.73
30.67 ± 2.50
84.40 ± 16.36
57.27 ± 5.68
Cord blood
18.53 ± 3.11
23.71 ± 2.16
15.43 ± 8.59
41.94 ± 18.98
Placenta villi
4.70 ± 2.71
4.70 ± 2.71
4.19 ± 3.01
4.76 ± 2.48
Placenta extravilli
4.85 ± 3.22
3.45 ± 1.64
10.65 ± 2.84
10.20 ± 6.91
CD16− CD56+
Maternal blood
1.36 ± 0.19
1.90 ± 0.15
1.45 ± 0.26
1.45 ± 0.26
Cord blood
0.50 ± 0.10
0.38 ± 0.15
2.76 ± 0.18
2.16 ± 0.18
Placenta villi
13.37 ± 5.56
66.74 ± 20.19
22.26 ± 16.11
5.11 ± 3.10
Placenta extravilli
16.49 ± 7.67
27.56 ± 13.00
30.17 ± 19.00
8.54 ± 2.15
CD16+ CD56+
Maternal blood
8.88 ± 3.34
6.69 ± 2.25
3.35 ± 1.02
6.70 ± 2.25
Cord blood
4.66 ± 2.56
5.87 ± 1.42
3.32 ± 2.20
5.88 ± 1.41
Placenta villi
3.13 ± 1.2
4.70 ± 1.92
4.20 ± 1.18
1.56 ± 0.55
Placenta extravilli
5.00 ± 1.1
7.46 ± 1.31
6.76 ± 1.04
3.68 ± 1.47
Note: results are expressed as the mean of samples of maternal blood, cord blood, and placental tissue. Statistical difference between ND and the other groups; #statistical difference between cells in placenta villi and placenta extravilli within the same group.
