Activated Circulating T Follicular Helper Cells Are Associated with Disease Severity in Patients with Psoriasis

Figure 3

Cytokine production by cTfh cells in patients with psoriasis vulgaris and healthy controls. (a) Represent profiles of IL-21, IFN-γ, IL-17, and IL-10 secreted by cTfh cells in psoriasis patients and healthy controls. (b) cTfh cells produce more IL-21, IFN-γ, and IL-17 in psoriasis patients than in healthy controls, whereas the secretion of IL-10 shows no significant difference between two groups. ; . (c) The higher expression of IL-21 on cTfh cells is positively correlated with the frequency of cTfh cells in patients with psoriasis vulgaris ().

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