Osteopontin Bridging Innate and Adaptive Immunity in Autoimmune Diseases

Table 1

OPN gene polymorphisms associated with autoimmune diseases.

SNP	rs	Located	Autoimmune disease	References
−156 G>GG	Rs7687316	Promoter	MS, T1D, SLE	[15, 16, 19]
−66 T>G	Rs28357094	Promoter	T1D, CD, SLE	[10, 19, 20]
+282 T>C	Rs4754	Exon VI	MS, SLE, ALPS/DALD, RA, CD	[10, 14, 21]
+750 C>T	Rs1126616	Exon VII	, PBC, MS, CD, ALPS/DALD	[10, 14, 21–23, 25]
+1083 A>G	Rs1126772	3′UTR	BD, , MS, ALPS/DALD, CD	[10, 13, 14, 16, 21, 24, 25]
+1239 A>C	Rs9138	3′UTR	CD, TDM1, MS, SLE, ALPS/DALD	[10, 13–16]

recent meta-analysis found an association only in Asian but not in European SLE patients () and no association with SLE patients () [25].
may have different numbering depending on the transcript analysed and the assembly used.