Journal of Immunology Research / 2016 / Article / Tab 1

Review Article

Crosstalk between Innate Lymphoid Cells and Other Immune Cells in the Tumor Microenvironment

Table 1

Involvement of ILC in different types of tumors. The three different ILC groups have been linked and have been shown to be associated with pro- or antitumor activities in diverse types of tumors. The mechanisms involved include secretion of cytokines and induction of changes in the tumor microenvironment that contribute to control of tumor growth or tumor progression and escape. For details, see main text.

ILC groupTumor typeEffectMechanism

ILC1Intestinal tumorsAntitumorSecretion of IFN-γ, activation of cytotoxic CD8+ T cells, inhibition of macrophage differentiation, and tumor angiogenesis
ILC2MelanomaAntitumorSecretion of IL-5 and recruitment of eosinophils
ILC2
Breast cancerProtumorTGF-β-mediated induction of MDSC and Treg
ILC2
CholangiocarcinomaProtumorIL-13-mediated proliferation
ILC3
Colon cancerProtumorInduction of inflammation by secretion of IL-17 and IL-22
ILC3Colon cancerProtumorIL-22-induced proliferation of tumor cells
ILC3
MelanomaAntitumorIncreased expression of ICAM and VCAM in tumor vasculature allows CD4+ and CD8+ infiltration

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