Journal of Immunology Research

Review Article

Crosstalk between Innate Lymphoid Cells and Other Immune Cells in the Tumor Microenvironment

Table 2

Cell markers that define human and mouse ILC.
MarkerILC1 ILC2 ILC3
NK cellsNoncytotoxic ILC1LTi NCR−ILC3NCR+ILC3
HMHMHMHMHMHM
CD4−−−−−−−+/−−Low−−
CD11c−−−−−−−−−−−−
CD25−/+−/+LowLowLowLowNDND++LowLow
CD56++−−NDND−−−−−/+−/+
CD117 −−−−+−/+HighHigh++LowLow
CD127 (IL-7Rα)−/+−/+−−++++++++
NKp44 (NCR2)−/+−−−−−−−−−+−
ICOSLowLow++++++++++
NKp46 (NCR1)++−−−−−−−−++
CRTH2 (CD294)−−−−++−−−−−−
IL-1R−−++++++++++
IL-23R−−−−NDND++++++
IL-12Rβ2++++−−−−−−−−
ST2−−−−++−−−−−−
IL-17RB−−−−++−−−−−−
NK1.1 (CD161)−/++−/+−+−−/+−ND−+−/+
Sca1 (Ly6A)−+−ND−+−−−+−ND
MHC class II−−−−−−++++−−
CCR6NDND+−−/+−+++−+−
There are differences between human and murine CD4 expression. Some murine LTi and a small number of NCR−ILC3 express CD4, whereas all human subsets are negative. NKp44 is only expressed in human cells. Sca1 (also known as Ly6A) is a mouse cell surface protein of the Ly6 family and is not found in human ILC. CCR6 expression in human and mouse ILC is different. In mice, CCR6 is not expressed in non-NK ILC1, ILC2, or NCR+ILC3. In humans, ILC1, ILC2, and NCR+ILC3 all express CCR6. CCR6, C-C chemokine receptor type 6; CRTH2, chemoattractant receptor-homologous molecule expressed on Th2 cells; ICOS, inducible T cell costimulator; IL, interleukin; ILC, innate lymphoid cell; LTi, lymphoid tissue inducer cells; MHC, major histocompatibility complex; NCR, natural cytotoxicity triggering receptor; ND, not determined; NK, natural killer; Sca1, stem cell antigen 1; H, human; M, mouse.