Journal of Immunology Research / 2016 / Article / Tab 2

Review Article

Crosstalk between Innate Lymphoid Cells and Other Immune Cells in the Tumor Microenvironment

Table 2

Cell markers that define human and mouse ILC.

MarkerILC1 ILC2 ILC3
NK cellsNoncytotoxic ILC1LTi NCRILC3NCR+ILC3
HMHMHMHMHMHM

CD4+/−Low
CD11c
CD25−/+−/+LowLowLowLowNDND++LowLow
CD56++NDND−/+−/+
CD117 +−/+HighHigh++LowLow
CD127 (IL-7Rα)−/+−/+++++++++
NKp44 (NCR2)−/++
ICOSLowLow++++++++++
NKp46 (NCR1)++++
CRTH2 (CD294)++
IL-1R++++++++++
IL-23RNDND++++++
IL-12Rβ2++++
ST2++
IL-17RB++
NK1.1 (CD161)−/++−/++−/+ND+−/+
Sca1 (Ly6A)+ND++ND
MHC class II++++
CCR6NDND+−/+++++

There are differences between human and murine CD4 expression. Some murine LTi and a small number of NCRILC3 express CD4, whereas all human subsets are negative. NKp44 is only expressed in human cells. Sca1 (also known as Ly6A) is a mouse cell surface protein of the Ly6 family and is not found in human ILC. CCR6 expression in human and mouse ILC is different. In mice, CCR6 is not expressed in non-NK ILC1, ILC2, or NCR+ILC3. In humans, ILC1, ILC2, and NCR+ILC3 all express CCR6. CCR6, C-C chemokine receptor type 6; CRTH2, chemoattractant receptor-homologous molecule expressed on Th2 cells; ICOS, inducible T cell costimulator; IL, interleukin; ILC, innate lymphoid cell; LTi, lymphoid tissue inducer cells; MHC, major histocompatibility complex; NCR, natural cytotoxicity triggering receptor; ND, not determined; NK, natural killer; Sca1, stem cell antigen 1; H, human; M, mouse.

We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.