Journal of Immunology Research / 2016 / Article / Tab 3

Review Article

Crosstalk between Innate Lymphoid Cells and Other Immune Cells in the Tumor Microenvironment

Table 3

Effector cytokines produced by ILC.

Cytokines
ILC1 ILC2 ILC3
NK cellsNoncytotoxic ILC1LTi NCRILC3NCR+ILC3

IFNγ+++
TNF++++
Perforin+
Granzyme+
IL-4−/+
IL-5+
IL-9+
IL-13+
IL-17A++
IL-22+++
Areg+
LT-α1β2+++
GM-CSF++++

Areg, amphiregulin; GM-CSF, granulocyte macrophage colony-stimulating factor; INFγ, interferon gamma; LT, lymphotoxin; and TNF, tumor necrosis factor.

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