Journal of Immunology Research / 2016 / Article / Fig 3

Review Article

IgE-Related Chronic Diseases and Anti-IgE-Based Treatments

Figure 3

Mechanism of action of OmAb. The two main described mechanisms of action of OmAb are (1) its ability to sequester free IgE and block its binding to IgE receptors (FcεRI) and (2) its ability to accelerate the dissociation of IgE bound to FcεRI in mast cells (MC) and basophils (BS). As a consequence, there is a reduction of IgE-triggered responses, as well as a reduction of the number of eosinophils (Eo), mast cells (MC), and basophils (BS). As a complementary mechanism, IgE complexed with OmAb may trap allergens (3). Another less understood mechanism would lead to a reduction of IgE+ B-cell numbers and a decrease of IgE synthesis (4). mIgE: membrane IgE.

We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.