IgE-Related Chronic Diseases and Anti-IgE-Based Treatments

Figure 3

Mechanism of action of OmAb. The two main described mechanisms of action of OmAb are (1) its ability to sequester free IgE and block its binding to IgE receptors (FcεRI) and (2) its ability to accelerate the dissociation of IgE bound to FcεRI in mast cells (MC) and basophils (BS). As a consequence, there is a reduction of IgE-triggered responses, as well as a reduction of the number of eosinophils (Eo), mast cells (MC), and basophils (BS). As a complementary mechanism, IgE complexed with OmAb may trap allergens (3). Another less understood mechanism would lead to a reduction of IgE⁺ B-cell numbers and a decrease of IgE synthesis (4). mIgE: membrane IgE.