Clinical Associations of Biallelic and Monoallelic TNFRSF13B Variants in Italian Primary Antibody Deficiency Syndromes

Table 4

Frequencies of clinical complications in patients with wild-type and TACI-mutated CVID.

	Wild-type	TACI mutated	value
Autoimmunity, (%)	39 (23)	10 (48)	0.03
Autoimmune cytopenia	22 (13)	9 (43)	0.002
Other autoimmune manifestations	27 (16)	3 (14)	ns
Lymphoproliferation, (%)	101 (60)	15 (71)	ns
Splenomegaly	96 (57)	14 (67)	ns
Lymphadenopathy	41 (25)	10 (48)	0.03
Granulomatous disease	19 (11)	6 (29%)	0.04
Malignant lymphoproliferation	15 (19)	1 (4%)	ns
Cancer, (%)	27 (20)	4 (17)	ns
Bronchiectasis, (%)	72 (43)	10 (53)	ns
Chronic diarrhea, (%)	42 (25)	5 (25)	ns