CXCL4 Contributes to the Pathogenesis of Chronic Liver Allograft Dysfunction

Figure 5

CXCL4 shRNA reduces the expression of fibrogenesis-associated proteins in isolated HSCs. (a) The isolated HSCs were transfected with CXCL4 shRNA for 72 hours. Western blot analysis of HSCs with antibodies against CXCR3, EGFR, JAK2, STAT3, and Collagen IV. (b) Quantitative presentation of these fibrogenesis-associated proteins. The CXCR3, EGFR, JAK2, STAT3, and Collagen IV levels in the CXCL4 shRNA-treated group decreased as a percent of their respective controls (untreated group). The data are presented as the mean ± SD, liver grafts per group. versus control group.

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