Brief Communication: Maternal Plasma Autoantibodies Screening in Fetal Down Syndrome

Table 2

The 213 statistically significant autoantibodies, whose expression decreased or increased in the group with fetal Down syndrome in comparison to the control group.

	Name of autoantibody: antibody directed against the following proteins	(if there is negative value, it is decreased autoantibody expression in Down syndrome group versus control group; if there is positive value, it is increased autoantibody expression in Down syndrome group versus control group)	value
1	Recombining binding protein suppressor of hairless (Drosophila) (RBPSUH), transcript variant 3, mRNA	1,60	0,00
2	Hematological and neurological expressed 1 (HN1), transcript variant 3	1,55	0,01
3	Hepatitis B virus x interacting protein (HBXIP)	1,54	0,02
4	Recombination signal binding protein for immunoglobulin kappa J region (RBPJ), transcript variant 4	1,45	0,00
5	Alcohol dehydrogenase, iron containing 1 (ADHFE1)	1,41	0,01
6	Transcription factor CP2-like 1 (TFCP2L1)	1,39	0,01
7	WW domain containing oxidoreductase (WWOX), transcript variant 3	1,33	0,03
8	Angiogenin, ribonuclease, RNase A family, 5, mRNA (cDNA clone MGC:61969 IMAGE:6453640), complete cds	1,28	0,01
9	Ephrin receptor B1 (EPHB1)	1,26	0,01
10	Spi-C transcription factor (Spi-1/PU.1 related) (SPIC)	1,22	0,01
11	SUMO1 activating enzyme subunit 2 (SAE2)	1,15	0,02
12	Family with sequence similarity 108, member B1 (FAM108B1)	1,11	0,00
13	SFRS protein kinase 1 (SRPK1)	1,04	0,02
14	FGF6 recombinant human protein	1,03	0,04
15	BTB/POZ domain containing protein KCTD18	1,01	0,03
16	Zinc finger CCHC domain containing protein 8	1,00	0,04
17	Mediator of RNA polymerase II transcription subunit 22	0,99	0,01
18	Minichromosome maintenance complex component 2 (MCM2)	0,99	0,03
19	ANKRD26-like family B member 1	0,98	0,00
20	Casein kinase 2, alpha prime polypeptide (CSNK2A2)	0,97	0,01
21	Lectin, Galactoside-Binding, Soluble, 14 (LGALS14), transcript variant 2	0,95	0,04
22	Stress 70 protein chaperone, microsome-associated, 60 kDa (STCH)	0,94	0,00
23	Suppressor of Ty 4 homolog 1 (S. cerevisiae) (SUPT4H1)	0,94	0,00
24	Ephrin type-B receptor 2	0,93	0,01
25	WD repeat domain 69 (WDR69)	0,92	0,02
26	Chromosome 6 open reading frame 206 (C6orf206)	0,92	0,02
27	v-akt murine thymoma viral oncogene homolog 1 (AKT1), transcript variant 3	0,91	0,04
28	Surfeit 5 (SURF5), transcript variant a	0,90	0,01
29	Calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha (CAMK2A), transcript variant 1	0,90	0,01
30	P antigen family, member 2 (prostate associated) (PAGE2)	0,88	0,03
31	Acyl-coenzyme A binding domain containing 7 (ACBD7)	0,88	0,03
32	Chromosome 18 open reading frame 32 (C18orf32)	0,87	0,04
33	mRNA similar to oocyte-specific histone H1 (cDNA clone MGC:50807 IMAGE:5742122), complete cds	0,86	0,04
34	Zinc finger protein SBZF3, mRNA (cDNA clone MGC:14334 IMAGE:4298348), complete cds	0,84	0,01
35	Protein DDI1 homolog 1	0,84	0,00
36	Proline-rich transmembrane protein 2 (PRRT2)	0,83	0,05
37	Mitogen-activated protein kinase kinase kinase 7 (MAP3K7), transcript variant B	0,82	0,04
38	Kv channel interacting protein 4 (KCNIP4), transcript variant 1	0,81	0,04
39	Nucleoredoxin	0,79	0,01
40	Hypothetical protein MGC40069 (MGC40069)	0,78	0,02
41	Chemokine (C-X-C motif) ligand 10, mRNA (cDNA clone MGC:13622 IMAGE:4274617), complete cds	0,77	0,04
42	Zinc finger, matrin type 5 (ZMAT5), transcript variant 1	0,77	0,00
43	Parvin, alpha (PARVA)	0,75	0,05
44	Interleukin-6	0,75	0,05
45	Eukaryotic elongation factor-2 kinase	0,75	0,04
46	Prefoldin subunit 4 (PFDN4)	0,74	0,02
47	Hypothetical protein FLJ10986 (FLJ10986)	0,74	0,03
48	Hypothetical protein MGC3020 (MGC3020)	0,73	0,03
49	Heat shock factor binding protein 1 (HSBP1)	0,73	0,02
50	Mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2)	0,72	0,03
51	Hypothetical protein MGC24103 (MGC24103)	0,72	0,02
52	Chromosome 7 open reading frame 36 (C7orf36)	0,72	0,05
53	Forkhead box P3 (FOXP3)	0,72	0,04
54	Ephrin receptor A1 (EPHA1)	0,71	0,02
55	ELL associated factor 1 (EAF1)	0,71	0,02
56	Exosome component 8 (EXOSC8)	0,70	0,02
57	Sialidase 4 (NEU4)	0,70	0,02
58	Activating signal cointegrator 1 complex subunit 2 (ASCC2)	0,70	0,03
59	Chemokine (C-C motif) ligand 13 (CCL13)	0,69	0,00
60	DNA-directed RNA polymerases I and III subunit RPAC1	0,69	0,01
61	Septin 4 (SEPT4), transcript variant 1	0,69	0,03
62	serine/threonine kinase	0,69	0,02
63	Protein tyrosine phosphatase, receptor type, O (PTPRO), transcript variant 3	0,68	0,01
64	Nudix (nucleoside diphosphate linked moiety X) type motif 2 (NUDT2), transcript variant 1	0,68	0,03
65	Protein phosphatase 1, regulatory (inhibitor) subunit 2 pseudogene 9 (PPP1R2P9)	0,68	0,03
66	Septin 4 (SEPT4), transcript variant 3	0,68	0,04
67	Nuclear receptor coactivator 5	0,68	0,03
68	WD repeat domain 53 (WDR53)	0,67	0,02
69	RAR-related orphan receptor B (RORB)	0,67	0,00
70	Chromosome 8 open reading frame 22 (C8orf22)	0,66	0,02
71	Chromosome 21 open reading frame 25 (C21orf25)	0,64	0,02
72	Albumin (ALB)	0,64	0,03
73	Chromosome 10 open reading frame 83 (C10orf83)	0,63	0,01
74	StAR-related lipid transfer (START) domain containing 10 (STARD10)	0,63	0,04
75	Minichromosome maintenance complex component 7 (MCM7)	0,62	0,04
76	Elastase 2B (ELA2B)	0,62	0,04
77	WD repeat domain 5B (WDR5B)	0,61	0,02
78	Exosome component 5 (EXOSC5)	0,61	0,04
79	Spleen focus forming virus (SFFV) proviral integration oncogene spi1 (SPI1), mRNA	0,59	0,04
80	fms-related tyrosine kinase 3 ligand (FLT3LG)	0,59	0,03
81	Hemoglobin, gamma A (HBG1)	0,59	0,03
82	Leukocyte-associated immunoglobulin-like receptor 2 (LAIR2), transcript variant 1	0,59	0,05
83	Forkhead box P1 (FOXP1)	0,58	0,03
84	Polymerase (DNA-directed), delta 4 (POLD4)	0,58	0,04
85	Hypothetical protein AL133206 (LOC64744), mRNA	0,58	0,02
86	Ubiquitin-conjugating enzyme E2L 6 (UBE2L6), transcript variant 1	0,57	0,03
87	Protein kinase C, beta 1 (PRKCB1), transcript variant 2	0,57	0,04
88	M-phase phosphoprotein 6 (MPHOSPH6)	0,57	0,01
89	Zinc finger protein 765 (ZNF765)	0,56	0,01
90	FtsJ homolog 1 (E. coli) (FTSJ1), transcript variant 1	0,56	0,04
91	Ring finger protein 128 (RNF128), transcript variant 1	0,56	0,02
92	TNFRSF1A/TNFRI/CD120a protein (His Tag)	0,55	0,05
93	Acid phosphatase 6, lysophosphatidic (ACP6)	0,55	0,02
94	Nucleophosmin (nucleolar phosphoprotein B23, numatrin) (NPM1)	0,55	0,02
95	Kelch domain containing 3 (KLHDC3), mRNA	0,55	0,03
96	N(6)-Adenine-specific DNA methyltransferase 1	0,55	0,05
97	RAB4A, member RAS oncogene family (RAB4A)	0,54	0,03
98	Zinc finger protein 396 (ZNF396), mRNA	0,54	0,02
99	kinesin family member 3A (KIF3A)	0,53	0,04
100	Poly(rC)-binding protein 2	0,53	0,05
101	WD repeat and FYVE domain containing 3 (WDFY3), transcript variant 3	0,53	0,05
102	Glycine N-methyltransferase (GNMT)	0,53	0,01
103	Histone H2B type 1-H	0,53	0,04
104	Tumor necrosis factor, alpha-induced protein 8-like 1 (TNFAIP8L1)	0,52	0,02
105	BRCA2 and CDKN1A interacting protein (BCCIP)	0,52	0,02
106	DnaJ (Hsp40) homolog, subfamily B, member 11 (DNAJB11)	0,52	0,05
107	Lamin-A/C	0,51	0,04
108	Seven in absentia homolog 1 (Drosophila) (SIAH1), transcript variant 2, mRNA	0,50	0,05
109	Ninjurin 2 (NINJ2)	−0,50	0,04
110	Trypsin-2	−0,50	0,02
111	PREDICTED (uORF:IOH62458~RFU:1604.5)	−0,51	0,04
112	Chromosome 20 open reading frame 39 (C20orf39)	−0,52	0,03
113	Dual specificity mitogen-activated protein kinase kinase 3	−0,52	0,04
114	Polymerase (RNA) III (DNA directed) polypeptide C (62 kDa) (POLR3C)	−0,52	0,03
115	Interleukin-1 receptor-associated kinase-like 2	−0,52	0,02
116	Adenylate kinase 2 (AK2), transcript variant AK2A	−0,53	0,05
117	pim-3 oncogene (PIM3)	−0,53	0,04
118	Chromosome 20 open reading frame 71 (C20orf71)	−0,53	0,04
119	LSM12 homolog (S. cerevisiae) (LSM12)	−0,54	0,03
120	Ring finger and CHY zinc finger domain containing 1 (RCHY1)	−0,54	0,02
121	Carbonic anhydrase X (CA10)	−0,55	0,02
122	Phosphoglucomutase 2-like 1 (PGM2L1)	−0,55	0,02
123	Membrane-associated ring finger (C3HC4) 10 (RNF190)	−0,56	0,05
124	Fructose-1,6-bisphosphatase 1 (FBP1)	−0,56	0,05
125	Myotubularin related protein 8 (MTMR8)	−0,57	0,02
126	Transient receptor potential cation channel subfamily M member 3	−0,57	0,04
127	ATP citrate lyase (ACLY)	−0,57	0,03
128	TNFSF10/APO2L/TRAIL/CD253 protein (native)	−0,58	0,04
129	Hypothetical protein FLJ33008 (FLJ33008), mRNA	−0,58	0,04
130	Proline rich 14 (PRR14)	−0,58	0,02
131	Interleukin 17C (IL17C), mRNA	−0,58	0,01
132	Upstream stimulatory factor 2	−0,58	0,02
133	Procollagen C-endopeptidase enhancer 1	−0,59	0,02
134	Thymine-DNA glycosylase (TDG)	−0,59	0,05
135	Matrix metallopeptidase 7 (matrilysin, uterine) (MMP7), mRNA	−0,59	0,04
136	DSN1, MIND kinetochore complex component, homolog (S. cerevisiae) (DSN1)	−0,60	0,02
137	PTK6 protein tyrosine kinase 6 (PTK6)	−0,60	0,05
138	Tubulin tyrosine ligase-like family, member 6 (TTLL6)	−0,60	0,01
139	Spastic paraplegia 21 (autosomal recessive, mast syndrome) (SPG21)	−0,61	0,04
140	Forkhead box M1, clone MGC:10704 IMAGE:3833837, mRNA, complete cds	−0,61	0,04
141	Embigin homolog (mouse) (EMB)	−0,62	0,04
142	Dynamin-2	−0,63	0,01
143	Mitogen-activated protein kinase-activated protein kinase 3 (MAPKAPK3)	−0,64	0,03
144	Runt-related transcription factor 1, translocated to 1 (cyclin D-related) (RUNX1T1), transcript variant 1	−0,64	0,04
145	Carnitine O-acetyltransferase	−0,64	0,01
146	Cell division cycle 25 homolog C (S. pombe) (CDC25C), transcript variant 1	−0,65	0,02
147	Menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis) (MNAT1)	−0,65	0,01
148	Obg-like ATPase 1 (GTPBP9)	−0,65	0,03
149	Rho GTPase activating protein 24 (ARHGAP24), transcript variant 2	−0,65	0,01
150	abl-interactor 1 (ABI1)	−0,66	0,05
151	Uncharacterized protein C6orf81	−0,66	0,05
152	1-Aminocyclopropane-1-carboxylate synthase-like protein 1	−0,67	0,02
153	Rho GTPase activating protein 12	−0,68	0,04
154	Mitogen-activated protein kinase kinase 3 (MAP2K3), transcript variant B	−0,68	0,00
155	Aminoadipate aminotransferase (AADAT)	−0,69	0,02
156	DCP1 decapping enzyme homolog B (S. cerevisiae), mRNA (cDNA clone MGC:44405 IMAGE:5296928), complete cds	−0,69	0,02
157	Calcium/calmodulin-dependent protein kinase kinase 1	−0,69	0,04
158	CD40 molecule, TNF receptor superfamily member 5 (CD40), transcript variant 1	−0,69	0,00
159	Signal peptide peptidase 3 (UNQ1887)	−0,69	0,00
160	MLCK protein (MLCK)	−0,70	0,04
161	Vacuolar protein sorting 24 homolog (S. cerevisiae) (VPS24), transcript variant 2	−0,70	0,02
162	LY6/PLAUR domain containing 1 (LYPD1), transcript variant 1	−0,71	0,02
163	Hypothetical protein FLJ31153 (FLJ31153), mRNA	−0,71	0,05
164	Fas apoptotic inhibitory molecule (FAIM), transcript variant 4	−0,71	0,05
165	ATR interacting protein (TREX1)	−0,72	0,03
166	EP300-interacting inhibitor of differentiation 3	−0,72	0,04
167	lin-7 homolog A (C, elegans) (LIN7A)	−0,73	0,02
168	Zeta-chain (TCR) associated protein kinase 70 kDa (ZAP70)	−0,73	0,05
169	Deleted in a mouse model of primary ciliary dyskinesia (RP11-529I10,4)	−0,74	0,04
170	N-ethylmaleimide-sensitive factor attachment protein, gamma (NAPG)	−0,74	0,02
171	Dynamin 2 (DNM2)	−0,74	0,00
172	Ribosomal protein L12 (RPL12)	−0,74	0,01
173	CD300 molecule-like family member g (CD300LG)	−0,75	0,00
174	4-Hydroxyphenylpyruvate dioxygenase	−0,75	0,04
175	Nuclease EXOG, mitochondrial	−0,76	0,01
176	Nuclear receptor coactivator 4 (NCOA4)	−0,76	0,02
177	Mitogen-activated protein kinase kinase kinase 14	−0,77	0,02
178	Chromosome 18 open reading frame 1 (C18orf1), transcript variant c2, mRNA	−0,77	0,04
179	Growth arrest-specific 2 (GAS2), transcript variant 2	−0,78	0,01
180	Transducin (beta)-like 1X-linked (TBL1X)	−0,79	0,03
181	Bone morphogenetic protein receptor, type IB (BMPR1B)	−0,79	0,03
182	Tropomodulin-2	−0,79	0,03
183	Calcium binding protein 39 (CAB39)	−0,81	0,03
184	Selectin P ligand (SELPLG)	−0,81	0,01
185	Neutrophil cytosolic factor 2 (65 kDa, chronic granulomatous disease, autosomal 2) (NCF2)	−0,82	0,02
186	Retinoic acid receptor, beta (RARB), transcript variant 2	−0,82	0,01
187	Potassium voltage-gated channel subfamily E member 1	−0,82	0,02
188	Interleukin-1 alpha	−0,82	0,01
189	Nucleoporin-like 1 (NUPL1), transcript variant 1	−0,82	0,01
190	HIG1 domain family, member 2A (HIGD2A)	−0,82	0,03
191	Pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) (PLRG1)	−0,83	0,01
192	Coiled-coil domain containing 76, mRNA (cDNA clone MGC:87928 IMAGE:5104751), complete cds	−0,83	0,02
193	GTPase activating protein (SH3 domain) binding protein 1 (G3BP1), transcript variant 2	−0,84	0,03
194	Golgi SNAP receptor complex member 1 (GOSR1), transcript variant 1	−0,84	0,04
195	Phosphoglucomutase 2	−0,84	0,03
196	RAS-like, family 11, member B (RASL11B)	−0,86	0,05
197	Proteasome subunit alpha type 1	−0,86	0,04
198	MAP3K12-binding inhibitory protein 1	−0,89	0,00
199	Zinc finger, DHHC-type containing 11 (ZDHHC11)	−0,91	0,02
200	Moesin (MSN)	−0,92	0,01
201	Guanine nucleotide exchange factor DBS	−0,92	0,01
202	Chromosome 13 open reading frame 16 (C13orf16)	−0,92	0,04
203	Regulator of G-protein signaling 14 (RGS14)	−0,97	0,03
204	LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) (LSM4)	−1,01	0,03
205	Fibronectin type III domain containing 4 (FNDC4)	−1,09	0,00
206	Myosin light chain kinase 2, skeletal muscle (MYLK2)	−1,12	0,03
207	HCG3 gene (HCG3)	−1,15	0,03
208	cAMP responsive element modulator (CREM), transcript variant 20, mRNA,	−1,31	0,03
209	TAF6 RNA polymerase II, TATA box binding protein (TBP) associated factor, 80 kDa (TAF6), transcript variant 1	−1,43	0,00
210	tec protein tyrosine kinase (TEC)	−1,76	0,03
211	Enolase 3 (beta, muscle) (ENO3)	−2,02	0,02
212	Chromosome 19 open reading frame 33 (C19orf33)	−2,40	0,02
213	26S proteasome non-ATPase regulatory subunit 7	−2,87	0,02