Table of Contents Author Guidelines Submit a Manuscript
Journal of Immunology Research
Volume 2017, Article ID 1017621, 7 pages
https://doi.org/10.1155/2017/1017621
Research Article

Genetic Polymorphisms of IL17 and Chagas Disease in the South and Southeast of Brazil

1Post Graduation Program of Biosciences and Physiopathology, Department of Analysis Clinical and Biomedicine, Maringa State University, Maringa, PR, Brazil
2Laboratory of Immunogenetics, Department of Molecular Biology, Medical School, São José do Rio Preto, SP, Brazil
3Laboratory of Immunogenetics, Department of Basic Health Sciences, Maringa State University, Maringa, PR, Brazil
4Department of Medical Clinic, Londrina State University, Londrina, PR, Brazil
5Department of Cardiology and Cardiovascular Surgery, Medical School, São José do Rio Preto, SP, Brazil

Correspondence should be addressed to Jeane Eliete Laguila Visentainer; moc.liamg@reniatnesivlej

Received 23 September 2016; Accepted 30 January 2017; Published 2 April 2017

Academic Editor: Margarete D. Bagatini

Copyright © 2017 Pâmela Guimarães Reis et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The aim of this study was to investigate possible associations between genetic polymorphisms of IL17A G197A (rs2275913) and IL17F T7488C (rs763780) with Chagas Disease (CD) and/or the severity of left ventricular systolic dysfunction (LVSD) in patients with chronic Chagas cardiomyopathy (CCC). The study with 260 patients and 150 controls was conducted in the South and Southeast regions of Brazil. The genotyping was performed by PCR-RFLP. The A allele and A/A genotype of IL17A were significantly increased in patients and their subgroups (patients with CCC; patients with CCC and LVSD; and patients with CCC and severe LVSD) when compared to the control group. The analysis according to the gender showed that the A/A genotype of IL17A was more frequent in female with LVSD and mild to moderate LVSD and also in male patients with LVSD. The frequency of IL17F T/C genotype was higher in male patients with CCC and severe LVSD and in female with mild to moderate LVSD. The results suggest the possible involvement of the polymorphisms of IL17A and IL17F in the susceptibility to chronic Chagas disease and in development and progression of cardiomyopathy.