Journal of Immunology Research / 2017 / Article / Tab 1

Research Article

Donor-Specific Anti-Human Leukocyte Antigen Antibodies Predict Prolonged Isolated Thrombocytopenia and Inferior Outcomes of Haploidentical Hematopoietic Stem Cell Transplantation

Table 1

Patient and donor characteristics.

Characteristics

Median age (range), years26 (2–58)
Male sex, n (%)231 (58.6%)
Diagnosis
 AML, n (%)160 (40.6%)
 ALL, n (%)133 (33.8%)
 CML, n (%)22 (5.6%)
 MDS, n (%)41 (10.4%)
 Others, n (%)38 (9.6%)
Disease status, SR (%)301 (76.4%)
Conditioning regimen
 MA, n (%)394 (100%)
Number of HLA-A, B, DR mismatched, n (%)
 03 (0.8%)
 122 (5.6%)
 287 (22.1%)
 3282 (71.6%)
Donor-recipient sex match, n (%)
 Male-male149 (37.8%)
 Male-female102 (25.9%)
 Female-male84 (21.3%)
 Female-female59 (15%)
Donor-recipient relationship, n (%)
 Father-child150 (38.1%)
 Mother-child57 (14.5%)
 Sibling-sibling117 (29.%)
 Child-parent58 (14.7%)
 Others12 (3.0%)
ABO matched, n (%)
 Matched224 (56.9%)
 Major mismatched74 (18.8%)
 Minor mismatched22 (5.6%)
 Bidirect mismatched74 (18.8%)
Cell compositions in allografts, median (range)
 Infused nuclear cells, 108/kg8.23 (1.78–23.69)
 Infused CD34+ cells, 106/kg2.61 (0.39–16.82)
 Infused lymphocytes, 108/kg2.93 (0.16–9.49)
 Infused CD3+ cells, 108/kg2.0 (0.1–5.93)
 Infused CD4+ cells, 108/kg1.1 (0.15–3.94)
 Infused CD8+ cells, 108/kg0.69 (0.05–2.47)
 Infused CD14+ cells, 108/kg1.48 (0.19–6.13)
aGVHD
 Grade 0-I aGVHD259 (65.7%)
 Grade II–IV aGVHD135 (34.3%)
cGVHD
 No cGVHD266 (67.5%)
 cGVHD128 (32.5%)