The Differential Contribution of the Innate Immune System to a Good Pathological Response in the Breast and Axillary Lymph Nodes Induced by Neoadjuvant Chemotherapy in Women with Large and Locally Advanced Breast Cancers
Table 1
Analyses of tumour-infiltrating CD68+ and CD163+ macrophages in the breast tumours in women with LLABCs and subsequent PCR following NAC.
Macrophages
Groups
Pre-NAC
Low infiltration (n)
High infiltration (n)
Pearson chi-square value (GPR versus PPR, PCR versus non-PCR)
value
CD68+ ()
Good pathological response (GPR, )
5
4
1.667
0.197
Poor pathological response (PPR, )
6
1
Pathological complete response (PCR, )
3
3
1.571
0.210
Nonpathological complete response (non-PCR, )
8
2
CD163+ ()
Good pathological response (GPR, )
5
16
8.192
0.004
Poor pathological response (PPR, )
9
3
Pathological complete response (PCR, )
3
13
7.127
0.008
Nonpathological complete response (non-PCR, )
11
6
LLABCs: large and locally advanced breast cancers; NAC: neoadjuvant chemotherapy; statistically significant.
