The Differential Contribution of the Innate Immune System to a Good Pathological Response in the Breast and Axillary Lymph Nodes Induced by Neoadjuvant Chemotherapy in Women with Large and Locally Advanced Breast Cancers
Table 8
Analyses of VEGF and IDO expression in the breast tumours in women with LLABCs (pre-NAC and post-NAC) and association with a PCR.
VEGF/IDO ()
Groups
Pre-NAC
Post-NAC
Low/negative expression (n)
High expression (n)
Pearson chi-square value (GPR versus PPR, PCR versus non-PCR)
value
Low/negative expression (n)
High expression (n)
Pearson chi-square value (GPR versus PPR, PCR versus non-PCR)
value
VEGF
Good pathological response (GPR, )
5
4
1.667
0.197
7
2
0.780
0.377
Poor pathological response (PPR, )
6
1
4
3
Pathological complete response (PCR, )
2
4
5.605
0.018
5
1
0.950
0.330
Nonpathological complete response (non-PCR, )
9
1
6
4
IDO
Good pathological response (GPR, )
6
3
0.042
0.838
6
3
0.152
0.696
Poor pathological response (PPR, )
5
2
4
3
Pathological complete response (PCR, )
3
3
1.571
0.210
4
2
0.071
0.790
Nonpathological complete response (non-PCR, )
8
2
6
4
VEGF: vascular endothelial growth factor; IDO: indoleamine 2,3-dioxygenase; LLABCs: large and locally advanced breast cancers; NAC: neoadjuvant chemotherapy; statistically significant.
