Plasma Levels of High-Mobility Group Box 1 during Peptide Vaccination in Patients with Recurrent Ovarian Cancer

Table 2

Comparison of HMGB1 and other biomarkers.

	IgG; response		CTL; response		Epitope; spreading		MDSC; increase		SAA; increase		CRP; increase		IL-6; increase
		n		n		n		n		n		n		n
HMGB1 increase (I)	Yes	2	Yes	1	Yes	0	Yes	0	Yes	1	Yes	1	Yes	2
	No	1	No	2	No	3	No	3	No	2	No	2	No	1
HMGB1 no change (NC)	Yes	23	Yes	18	Yes	17	Yes	4	Yes	9	Yes	16	Yes	11
	No	3	No	8	No	9	No	20	No	17	No	10	No	15
HMGB1 decrease (D)	Yes	8	Yes	6	Yes	6	Yes	2	Yes	5	Yes	5	Yes	3
	No	2	No	4	No	4	No	8	No	5	No	5	No	7
value^†
I versus not I (NC+D)		0.3698		0.2475		0.0307		0.4267		0.8493		0.4015		0.3473
D versus not D (NC+I)		0.639		0.7538		0.939		0.7039		0.3844		0.6355		0.4111
							MDSC; decrease		SAA; decrease		CRP; decrease		IL-6; decrease
							n = 37		n = 39		n = 39		n = 39
								n		n		n		n
HMGB1 increase (I)							Yes	1	Yes	0	Yes	0	Yes	0
							No	2	No	3	No	3	No	3
HMGB1 no change (NC)							Yes	3	Yes	3	Yes	2	Yes	1
							No	21	No	23	No	24	No	25
HMGB1 decrease (D)							Yes	0	Yes	1	Yes	2	Yes	1
							No	10	No	9	No	8	No	9
value
I versus not I (NC+D)								0.19		0.5422		0.5422		0.6751
D versus not D (NC+I)								0.1975		0.9753		0.2389		0.418

^† values of chi-square test are shown; statistically significant.