Humoral Responses to Rv1733c, Rv0081, Rv1735c, and Rv1737c DosR Regulon-Encoded Proteins of Mycobacterium tuberculosis in Individuals with Latent Tuberculosis Infection
Table 2
Associations between Mycobacterium tuberculosis infection status and concentrations of IgG antibodies to DosR proteins and CFP-10/ESAT-6 in study participants.
Antibody/factor
Crude geometric mean ratio (95% CI)
value
Adjusted geometric mean ratio (95% CI)1
value
Anti-Rv1733c antibodies
Uninfected
1
1
LTBI
1.374 (0.915–2.063)
0.125
1.240 (0.792–1.942)
0.346
APTB
1.346 (0.916–1.974)
0.131
1.370 (0.904–2.078)
0.138
Anti-Rv0081 antibodies
Uninfected
1
1
LTBI
1.437 (0.761–2.714)
0.264
1.382 (0.700–2.727)
0.343
APTB
1.790 (1.007–3.184)
0.047
1.707 (0.956–3.046)
0.071
Anti-Rv1735c antibodies
Uninfected
1
1
LTBI
1.203 (0.774–1.869)
0.411
1.059 (0.651–1.722)
0.818
APTB
1.529 (1.058–2.210)
0.024
1.333 (0.912–1.949)
0.138
Anti-Rv1737c antibodies
Uninfected
1
1
LTBI
1.147 (0.704–1.868)
0.581
1.122 (0.650–1.938)
0.680
APTB
1.479 (0.966–2.264)
0.072
1.352 (0.801–2.282)
0.259
Anti-CFP-10/ESAT-6 antibodies
Uninfected
1
1
LTBI
1.162 (0.682–1.981)
0.580
1.019 (0.567–1.829)
0.951
APTB
2.199 (1.415–3.418)
<0.001
2.020 (1.279–3.190)
0.003
LTBI = latent tuberculosis infection; APTB = active pulmonary tuberculosis. 1Regression analyses were performed with bootstrap confidence intervals generated from 1000 replicate samples of data. The data was from 68 individuals who were uninfected, 62 with LTBI, and 105 with APTB. Adjusting was done for age, gender, and HIV infection status. Analysis was performed on log transformed values and back-transformed to provide geometric mean ratios.
