Humoral Responses to Rv1733c, Rv0081, Rv1735c, and Rv1737c DosR Regulon-Encoded Proteins of Mycobacterium tuberculosis in Individuals with Latent Tuberculosis Infection

Table 3

Associations between Mycobacterium tuberculosis infection status and concentrations of IgG antibodies to Rv1733c and Rv0081 DosR proteins in male and female study participants, after adjusting for potential confounders.

Antibody/factor	Adjusted geometric mean ratio (95% CI)^1	value
Anti-Rv1733c antibodies in males
Uninfected	1
LTBI	0.670 (0.292–1.538)	0.345
APTB	1.041 (0.636–1.704)	0.873
Anti-Rv1733c antibodies in females
Uninfected	1
LTBI	1.812 (1.105–2.973)	0.019
APTB	1.718 (0.877–3.369)	0.115
Anti-Rv0081 antibodies in males
Uninfected	1
LTBI	0.631 (0.300–1.331)	0.227
APTB	1.183 (0.674–2.075)	0.558
Anti-Rv0081 antibodies in females
Uninfected	1
LTBI	2.229 (0.833–5.966)	0.111
APTB	2.484 (0.948–6.505)	0.064

LTBI = latent tuberculosis infection and APTB = active pulmonary tuberculosis.
¹Regression analyses were performed with bootstrap confidence intervals generated from 1000 replicate samples of data. The data was from 29 uninfected males, 21 males with LTBI, 62 males with active PTB, 39 uninfected females, 41 females with LTBI, and 43 females with APTB. The value for interaction was 0.06 for Rv1733c and 0.04 for Rv0081. Adjusting was done for age and HIV infection status. Analysis was performed on log transformed values and back-transformed to provide geometric mean ratios.