Regulatory T Cells and Their Prognostic Relevance in Hematologic Malignancies

Table 4

Most relevant published studies investigating the frequency and the prognostic significance of Tregs in acute leukemias.

Reference	Patients/controls evaluated	Samples tested	Marker panel used in Treg evaluation by flow cytometry	Treg frequency	Functional studies	Impact on prognosis
Bhattacharya et al. [58]	B-ALL	PBMC /BM	CD4/CD25/CD127/FoxP3	Decreased	Higher suppressive capability on CD4^+CD25^− regulatory T cells than controls	Increased frequency with disease progression
Wu et al. [59]	B-ALL/T-ALL/controls	PB	CD4/CD25	Higher	Not performed	Not evaluated
Wang et al. [60]	AML/controls	PBMC /BM	CD4/CD25	Higher	Inhibition of proliferation and cytokine production (IL2, IFN-γ) of CD4^+CD25^−T cells; improved IL-10 production under coculture of both subsets with stimulation	Not evaluated
Idris et al. [61]	B-ALL/controls	PB and BM	CD4/CD25/CD127	Increased	Not performed	Correlation with age

ALL: acute lymphoblastic leukemia; AML: acute myeloid leukemia; PB: peripheral blood; BM: bone marrow; PBMC: peripheral blood mononuclear cells; IL: interleukin; IFN: interferon.