Table of Contents Author Guidelines Submit a Manuscript
Journal of Immunology Research
Volume 2017, Article ID 2012585, 8 pages
https://doi.org/10.1155/2017/2012585
Research Article

Protective Effects of Ophiocordyceps lanpingensis on Glycerol-Induced Acute Renal Failure in Mice

1Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan 650500, China
2Tumor Research Institute of Yunnan Province, The Third Affiliated Hospital of Kunming Medical University (Yunnan Tumor Hospital), Kunming, Yunnan 650118, China
3School of Life Sciences, Yunnan University, Kunming, Yunnan 650500, China
4The Research Center of Cordyceps Development and Utilization of Kunming, Kunming, Yunnan 650100, China

Correspondence should be addressed to Feng Ge; moc.361@specydrocxanap

Received 15 June 2017; Accepted 9 August 2017; Published 12 October 2017

Academic Editor: Yong Tan

Copyright © 2017 Yanyan Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. Oxidative stress and immune response are associated with acute renal failure (ARF). Ophiocordyceps lanpingensis (OL) might be an antioxidant and immunopotentiator. In this study, we explored the protective effects of OL on glycerol-induced ARF. Methods. Male mice were randomly divided into four groups, specifically, glycerol-induced ARF model group, low-dose OL-treated group (1.0 g/kg/d), high-dose OL-treated group (2.0 g/kg/d), and control group. Renal conditions were evaluated using kidney index, serum creatinine (Cr), blood urea nitrogen (BUN), and histological analysis. Rhabdomyolysis was monitored using creatine kinase (CK) level. Oxidative stress was determined using kidney tissue glutathione (GSH), malondialdehyde (MDA), and superoxide dismutase (SOD) levels. Immune status was evaluated using immune organ indices and immunoglobulin G (IgG) level. Results. OL could relieve renal pathological injury and decrease the abnormal levels of kidney index, serum Cr, CK, BUN, and MDA, as well as increase the immune organ indices and the levels of IgG, GSH, and SOD. Treatment with a high dose of OL had more positive therapeutic effects on ARF than using a low dose of OL. Conclusion. OL could ameliorate renal dysfunction in glycerol-induced ARF in mice by inhibiting oxidative stress and enhancing immune response.