Polymorphisms of IL12RB2 May Affect the Natural History of Primary Biliary Cholangitis: A Single Centre Study

Table 3

The IL12RB2 polymorphisms (rs3790567, rs6679356) association with cirrhosis in PBC.

SNP	Genotype	Cirrhosis ()		Fisher exact; value		OR
		No (%)	Yes (%)
rs3790567	A/G	83 (25%)/247 (75%)	84 (38%)/138 (62%)	0.001	10.12	1.8 [1.3–2.6]
	AA	12 (7.3%)	16 (14.4%)	NS	3.71	2.1 [0.9–4.7]
	AG	59 (35.7%)	52 (46.9%)	NS	3.39	1.6 [0.9–2.6]
	GG	94 (57%)	43 (38.7%)	0.003	8.82	0.5 [0.3–0.8]
rs6679356	C/T	69 (20.8%)/263 (79.2%)	68 (31%)/152 (69%)	0.013	7.27	1.7 [1.1–2.5]
	CC	10 (6%)	12 (10.9%)	NS	2.15	1.9 [0.8–4.6]
	CT	49 (29.5%)	44 (40%)	NS	3.25	1.6 [0.9–2.6]
	TT	107 (64.5%)	54 (49.1%)	0.009	6.43	0.5 [0.3–0.9]