Sirtuin 2 Regulates Microvascular Inflammation during Sepsis

Figure 2

Platelet adhesion with SIRT2 modification. Platelet adhesion in the small intestinal microcirculation in sepsis groups was significantly increased versus that in the respective sham groups ( in each group). Platelet adhesion in SIRT2KO sepsis mice was not significantly increased versus that in WT sepsis; platelet adhesion in SIRT2KI sepsis mice was not significantly different versus that in WT sepsis mice. Platelet adhesion in SIRT2KI sepsis mice was significantly decreased versus that in SIRT2KO sepsis mice. Platelet adhesion in WT, SIRT2KO, and SIRT2KI sham mice were not significantly different from each other. versus respective sham; ^# versus WT sepsis using Tukey’s post hoc analysis; error bars: sem.