Sirtuin 2 Regulates Microvascular Inflammation during Sepsis

Figure 5

SIRT2 modification impacts sepsis survival. We studied 7-day survival rates in WT, SIRT2KO, and SIRT2KI mice with sepsis. WT sepsis mice showed a 40% 7-day survival rate; SIRT2KO sepsis mice was 10% while SIRT2KI sepsis mice showed an 80% 7-day survival rate.