The Immunogenicity of HLA Class II Mismatches: The Predicted Presentation of Nonself Allo-HLA-Derived Peptide by the HLA-DR Phenotype of the Recipient Is Associated with the Formation of DSA

Table 5

Association between the nature (self or nonself) of the peptide predicted to bind with highest affinity to the recipient’s HLA-II antigens and the presence of DSA.

Peptide length	HLA class II presentation	Allo-HLApep	DSA	No DSA	value
9 mers	HLA-DR	Nonself	15	3	0.0169
		Self	2	5
	HLA-DQ	Nonself	5	4	0.3942
		Self	12	4
	Combined (HLA-DR and HLA-DQ)	Nonself	15	6	0.57
		Self	2	2
12 mers	HLA-DR	Nonself	14	5	0.3442
		Self	3	3
	HLA-DQ	Nonself	5	6	0.081
		Self	12	2
	Combined (HLA-DR and HLA-DQ)	Nonself	14	8	0.527
		Self	3	0
15 mers	HLA-DR	Nonself	14	6	1
		Self	3	2
	HLA-DQ	Nonself	8	6	0.2337
		Self	9	2
	Combined (HLA-DR and -DQ)	Nonself	15	8	1
		Self	2	0

Note. Fisher’s exact test two-tailed values are shown.