Neutrophil Extracellular Traps and Microcrystals

Table 1

Microcrystals that trigger NET formation.

Crystal name	Clinical relevance	Requirement of the following				References
		NADPH oxidase	PAD4	MPO	NE
Monosodium urate (MSU)	Gout	Yes	?	?	No	[7, 19, 23, 25–28]
Calcium pyrophosphate dehydrate crystals (CPPD)	Pseudogout	No	?	?	?	[29]
Cholesterol crystals	Atherosclerosis	Yes	No	?	Yes	[30]
Silica crystals	Silicosis	?	?	?	?	[31]
PMA (in comparison)	—	Yes	?	Yes	Yes	[2, 9, 32]