Pathogenic Roles of Glutamic Acid Decarboxylase 65 Autoantibodies in Cerebellar Ataxias

Figure 1

(a) Schematic diagram of electric stimulation experiment in vivo. (b) Schematic diagram of effects of GAD65Ab in the cerebellar circuit. PC: Purkinje cell, GC: granule cells, PF: parallel fiber, MF: mossy fiber, GABAergic IN: GABAergic interneuron, CN: Cerebellar nuclei. Arrows in (b) indicate the flow of signals in the cerebellar cortex. The CN neurons receive weak MF collaterals in the cerebrocerebellum and strong collaterals in other areas. Thus, the MF collateral is indicated by a dotted line. These figures were modified from our previous references [7, 30, 31].

(a)

(b)