Pathogenic Roles of Glutamic Acid Decarboxylase 65 Autoantibodies in Cerebellar Ataxias

Table 2

Summary of experiments showing internalization of antibodies into cerebellar neurons.

Preparation	Detected internalized antibodies	Portion of internalization	Reference
In vitro incubation of rat cerebellum with human or rat IgGs and IgMs	IgG, IgM	Purkinje cells	[46]
Autopsy; Brain tissue of patient with multiple myeloma	Myeloma light chain	Purkinje cells	[47]
Autopsy; Brain tissue of rats	IgG	Purkinje cells, specific neuronal nuclei	[48]
Autopsy; Cerebellar tissues of patients	IgG, IgA, IgM	Purkinje cells	[49]
Intraventricular injection of human IgGs into guinea pigs	IgG	Purkinje cells	[50]
Peripherally administered human IgG in rats.	IgG	Purkinje cells	[51]