Saliva-Derived Host Defense Peptides Histatin1 and LL-37 Increase Secretion of Antimicrobial Skin and Oral Mucosa Chemokine CCL20 in an IL-1α-Independent Manner

Figure 1

Cell viability after exposure to Hst1 and LL-37. Cell viability is shown after 24-hour exposure to Hst1 and LL-37 of (A) keratinocyte monolayer, (B) fibroblast monolayer, (C) keratinocyte-fibroblast coculture, and (D) keratinocyte-fibroblast coculture with neutralizing antibodies to IL-1α (white bars) or isotype control (black bars). Each bar represents the mean ± standard error mean of 3 independent experiments each performed in duplicate, except that in (D) (). , , and .