Saliva-Derived Host Defense Peptides Histatin1 and LL-37 Increase Secretion of Antimicrobial Skin and Oral Mucosa Chemokine CCL20 in an IL-1α-Independent Manner

Figure 3

Inflammatory cytokine secretion after Hst1 and LL-37 exposure. Skin or gingiva cells were exposed to either Hst1 or LL-37 for 24 hours, and cytokine secretion was assessed by ELISA. (a) IL-1α and CCL27 secretion by keratinocyte monocultures; (b) IL-6, CCL2, CXCL1, and CXCL8 secretion by fibroblast monocultures. Each bar represents the mean ± standard error mean of 3 independent experiments each performed in duplicate. and .

(a)

(b)