Saliva-Derived Host Defense Peptides Histatin1 and LL-37 Increase Secretion of Antimicrobial Skin and Oral Mucosa Chemokine CCL20 in an IL-1α-Independent Manner

Figure 5

Inflammatory cytokine secretion by keratinocyte-fibroblast cocultures is blocked by neutralizing antibodies to IL-1α. IL-6, CCL2, CXCL1, and CXCL8 secretion by skin and gingiva keratinocyte-fibroblast cocultures after 24-hour exposure to Hst1 and LL-37, together with either neutralizing antibodies to IL-1α (white bars) or isotype control (black bars). Each bar represents the mean ± standard error mean of 3 independent experiments each performed in duplicate. , , and .