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Journal of Immunology Research
Volume 2017, Article ID 3186328, 10 pages
https://doi.org/10.1155/2017/3186328
Review Article

HLA Association with Drug-Induced Adverse Reactions

1Whole-Genome Research Core Laboratory of Human Diseases, Chang Gung Memorial Hospital, Keelung, Taiwan
2Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Linkou, Taipei, Taiwan
3Research Center, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
4Chang Gung Immunology Consortium, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan
5Department of Dermatology, Xiamen Chang Gung Hospital, Xiamen, China
6College of Medicine, Chang Gung University, Taoyuan, Taiwan

Correspondence should be addressed to Wen-Hung Chung; moc.oohay@gnuhcgnuhnew

Received 1 September 2017; Accepted 24 October 2017; Published 23 November 2017

Academic Editor: Mahboobeh Mahdavinia

Copyright © 2017 Wen-Lang Fan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Adverse drug reactions (ADRs) remain a common and major problem in healthcare. Severe cutaneous adverse drug reactions (SCARs), such as Stevens–Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) with mortality rate ranges from 10% to more than 30%, can be life threatening. A number of recent studies demonstrated that ADRs possess strong genetic predisposition. ADRs induced by several drugs have been shown to have significant associations with specific alleles of human leukocyte antigen (HLA) genes. For example, hypersensitivity to abacavir, a drug used for treating of human immunodeficiency virus (HIV) infection, has been proposed to be associated with allele 57:01 of HLA-B gene (terms HLA-B57:01). The incidences of abacavir hypersensitivity are much higher in Caucasians compared to other populations due to various allele frequencies in different ethnic populations. The antithyroid drug- (ATDs- ) induced agranulocytosis are strongly associated with two alleles: HLA-B38:02 and HLA-DRB108:03. In addition, HLA-B15:02 allele was reported to be related to carbamazepine-induced SJS/TEN, and HLA-B57:01 in abacavir hypersensitivity and flucloxacillin induced drug-induced liver injury (DILI). In this review, we summarized the alleles of HLA genes which have been proposed to have association with ADRs caused by different drugs.