HLA Association with Drug-Induced Adverse Reactions

Table 1

Drug-induced ADRs and HLA allele associations.

Drug	HLA allele	Phenotype	Population	Reference
Abacavir	B57:01	HSS	Australian	[25]
			African American	[26]
			Brazilian	[79]
			British	[24]
			Indian	[80]
			Iranian	[81]
Carbamazepine	B15:02	SJS/TEN	Taiwanese	[35, 82]
			Han Chinese	[83]
			Thai	[37]
			Malaysian	[44]
			Asian	[46]
	A31:01	MPE, HSS, SJS/TEN	Han Chinese	[49, 82]
			Caucasian	[48]
			Japanese	[50]
	B15:11	SJS/TEN	Japanese	[47, 84]
Allopurinol	B58:01	SJS/TEN	Han Chinese	[53]
			Caucasian	[57]
			Thai	[59]
			Japanese	[59]
		SCARS	Taiwanese	[85]
Dapsone	B13:01	HSS		[60]
Phenytoin	B15:02	SJS/TEN	Han Chinese	[83]
			Thai	[37]
Lamotrigine	A31:01	HSS	British	[86]
	B15:02	SJS/TEN	Han Chinese	[83]
Nevirapine	DRB101:01	DRESS	Hispanics, African	[87]
	B14:02	HSS	Sardinian	[88, 89]
Sulphamethoxazole	B38	SJS/TEN	European	[57]
Methazolamide	B59:01, CW01:02	SJS/TEN	Korean and Japanese	[84]
Amoxicillin-clavulanate	DRB115:01-DQB106:02	DILI	Caucasian	[64]
Flucloxacillin	B57:01	DILI	Caucasian	[65]
Lumiracoxib	DRB115:01	DILI	Not available	[90]
Ticlopidine	A33:03	DILI	Japanese	[91]
Antithyroid drugs	B38:02-DRB108:03	Agranulocytosis	Taiwanese	[16]