HLA Association with Drug-Induced Adverse Reactions

Table 2

Available genetic tests.

Platform	Technology	Specificity	Advantage	References
PCR	Sequence specific oligonucleotides (SSO)	>95%	Commercial kits available	[66, 92]
PCR	sequence-specific primer (SSP) PCR	>97%	More specific than SSO	[66, 68, 69]
Real-time PCR	Hydrolysis probe (TaqMan)	>99%	Mismatch in the probe region seems to be more sensitive than those in the primer region	[73]
Flow cytometry	HLA-B17 specific monoclonal antibody	~80%		[93]
Patch testing		60–70%	Safe and inexpensive	[75, 76]