Journal of Immunology Research

Review Article

The Role of Humoral Alloreactivity in Liver Transplantation: Lessons Learned and New Perspectives

Table 2

Summary of reported cases of acute antibody-mediated rejection following ABO-compatible liver transplantation.


Reference	Age/gender	Onset of graft dysfunction	DSA detection method	Type of DSA	DSA specificity	AMR treatment	Clinical outcome

Rostron et al. (2005) [22]	23/F	POD 6	Luminex SAB	Preformed	Bw6	Steroids, MMF, PP, IVIG	Alive with functioning graft

Wilson et al. (2006) [23]	36/F	4 years	Luminex SAB	De novo	DR52	Steroids, MMF, PP, IVIG, Rituximab, ATG	Alive with functioning graft

Watson et al. (2006) [24]	50/F	POD 5	Flow cytometry SAB	Preformed	B7	Steroids, MMF, PP, IVIG, Rituximab	Death

Kamar et al. (2009) [25]	49/F	POD 10	Luminex SAB	Preformed	A2, DR7	Steroids, MMF, PP, Rituximab, OKT3	Death
Kamar et al. (2009) [25]	39/F	POD 6	Luminex SAB	Preformed	A2, A24, B27, DR4	Steroids, PP, Rituximab	Alive with functioning graft

Kozlowski et al. (2011) [26]	N/A	POD 5	Flow cytometry or Luminex SAB	Preformed	3 DSA (specificity not provided)	Steroids, PP, IVIG, Rituximab	Death
	N/A	POD 7		Preformed	A30, A74, B7, B45, DR15, DR51, DQ7	Steroids, PP, IVIG, Rituximab, ATG	Death
	N/A	POD 7		Preformed	4 DSA (specificity not provided)	Steroids, PP, IVIG, Rituximab, OKT3	Retransplant, alive

Paterno et al. (2012) [27]	62/F	POD 8	Luminex SAB	De novo	DR13, DR15, DR51, DR52	Steroids, OKT3, ATG, Bortezomib	Alive with functioning graft
	28/F	POD 452	Luminex SAB	De novo	DQ2, DQ6	Steroids, PP, Rituximab, ATG, Bortezomib	Alive with functioning graft
	53/F	POD 6	Luminex SAB	Preformed	B51, Cw2, DQ7	Steroids, ATG, Bortezomib	Alive with functioning graft

Kheradmand et al. (2014) [28]	43/F	POD 1	Luminex SAB	Preformed	B35, B51, DR4, DR53, DQ8	Steroids, PP, IVIG, Rituximab, ATG	Alive with functioning graft

Wozniak et al. (2016) [29]	22 mo/M	POD 45	Luminex SAB	De novo	B44, DQ2	Steroids, MMF, IVIG, Rituximab	Alive with functioning graft
	3/F	POD 13	Luminex SAB	N/A	A1, DQ5	Steroids, MMF, IVIG	Alive with functioning graft
	19 mo/F	POD 8	Luminex SAB	Preformed & de novo	Cw7, Cw17, DR4, DR53, DQ8	Steroids, MMF, IVIG, Rituximab	Alive with functioning graft
	11/M	POD 7	Luminex SAB	De novo	DR53, DQ8	Steroids, MMF, PP, IVIG, ATG, Bortezomib	Alive with functioning graft
	6 mo/M	POD 38	Luminex SAB	De novo	DQ7, DQ9	Steroids, MMF, PP, IVIG, Rituximab	Retransplant, death
	3/M	POD 7	Luminex SAB	Preformed	A1, B8, Cw7, DR17, DQ2, DP1	Steroids, MMF, PP, IVIG, Rituximab, Bortezomib, Eculizumab	Alive with functioning graft

N/A, not available/information not provided; SAB, single antigen bead-based testing; PP, plasmapheresis; IVIG, intravenous immunoglobulin; ATG, antithymocyte globulin.