Identification of Palmitoleic Acid Controlled by mTOR Signaling as a Biomarker of Polymyositis

Figure 1

Screening of altered metabolites controlled by mTORC1 signaling. (a) A model showing the procedure of human PBMC cell culture and drug treatment. Rapamycin (100 nM) and Torin1 (200 nM) treatment time is 24 h. (b) A diagram showing the results of metabolites screening. Note that the crossing of the rapamycin and Torin1 groups contains about 7 substrates, including palmitoleic acid. (c) The molecular structure of palmitoleic acid.

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