Identification of Palmitoleic Acid Controlled by mTOR Signaling as a Biomarker of Polymyositis

Figure 3

mTORC1 signaling regulates palmitoleic acid level through its de novo synthesis. (a) A model showing the de novo lipid synthesis in mammalian cells. mTORC1 mainly regulates gene transcriptions of Srebp1c, Acc1, Fasn, and Scd1 by SREBP1. (b) Real-time PCR results showed the decreased gene expressions of Srebp1c, Acc1, Fasn, and Scd1 in cells treated with rapamycin. Results are averages of three independent experiments. Data represent mean ± SEM. , , and . (c) Real-time PCR results showed the increased gene expressions of Srebp1c, Acc1, Fasn, and Scd1 in cells by TSC1 KD. Results are averages of three independent experiments. Data represent mean ± SEM. and .

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